The first reported fat transfer was reported as early as 1893 by a German physician, named Franz Neuber, who injected fat to improve a facial pit caused by tuberculosis complications. Just 2 years later, another German physician, named Czerny transferred fat to the breast. This surgery was also considered the first documented breast augmentation in the world. For nearly a century fat transfer never gained popularity due to poor survivability following transplantation. For the last two decades, largely due to the efforts of a U.S. surgeon, Dr. Sidney Coleman, fat transfer has come back into vogue.

Good candidates for fat transfer/grafting procedure are patients who require filling of void spaces, wrinkles, folds, contour deficits, etc. These theoretical considerations result in a number of indications for surgical fat grafting. Recently, it has been recognized that patients who demonstrate facial aging signs such as drooping and sagging of tissues also demonstrate loss of volume. This loss of volume has been attributed to deflation of the fat underlying the skin. Several areas can now be successfully filled by fat grafting including the cheeks, jawline, laugh lines extending from the corner of the lip (those extending up are called nasolabial folds; those extending downward are called marionette lines), in the hollow of the lower eyelids, temple region, under the eyebrows, under the upper eyelid(if fat was over-resection following upper eyelid surgery), and the lips. Patients who have previously undergone liposuction by injection techniques or SMART lipo often present with contour deformities such as pitting, etc. These areas may be filled with fat grafting. Finally, patients who have failed breast augmentation with implants or breast reconstruction patients with residual contour deformities may benefit from breast mound filling or revision by fat grafting.

Fat grafting involves transferring of fat from areas with generous fat supply to areas lacking in fat content or areas requiring filling such as void spaces, wrinkles, folds, and contour deficits. Fat must be harvested using modified liposuction techniques which are meant to preserve fat cells. These modifications include lowering the pressure of the suction to less than 15mm Hg pressure instead of 25 to 30 mm Hg pressure used routinely during liposuction. In addition, the fat cells are handled gently while removing the excess fluid(plasma) from the fat. Finally, the fat cells are washed with 1 L lactated ringers fluid mixed with 80mg of Gentamycin. These fat cells must be harvested, processed, and transferred expediently in order to minimize outside exposure period. Fat cells are then loaded into syringes and injected into the tissue in order to sculpt and correct above discussed deformities. In order to ensure re-establishment of transplanted fat cell vascular supply, fat cells are transplanted in 0.1 to 0.2ml micropackets. Transplanting fat cells in micropackets maximizes surface area to volume thus optimizing re-establishment of vascular supply. Areas that are grafted will be gently and smoothly wrapped in order to maintain fat cells in their transferred location. Liposuctioned areas are also dressed with compression garments to ensure a smooth contour.

On your initial visit, your surgeon will evaluate your health status by obtaining blood work. If you are 50 years or older you will need to have an EKG of your heart to rule out any heart conditions. If you are a smoker, you should quit for 1 month prior to and six weeks following your fat grafting surgery to maximize your rate of fat graft take. The limitation of fat transfer/grafting surgery is the rate of fat graft take which is dictated by the rate at which transplanted fat cells regain their vascularity and thus preserve their viability. Since the fat cells are avulsed from their home and transplanted to a new environment, they must establish their vascular blood supply in order to survive. This effectiveness of fat cells to re-establish this vascular supply determines the success of fat grafting take and over all success. Nicotine adversely effects the small vessels of the skin and is detrimental to re-establishing the blood supply to fat cells. Finally, you will need to arrange for a friend if you don’t have a spouse to care for any small children who may need to be lifted or carried for the first few days following surgery.

Since your surgery will require general anesthesia, you must take several precautions prior to surgery. First, you will have to avoid eating and drinking after midnight on the day before surgery. This precaution ensures that your stomach is clear of digested foods that could potentially be aspirated and contaminate your lungs during induction of anesthesia. Since, you will have anesthetic medications administered throughout the case, you will remain groggy for several hours and will require a ride to and from the surgery center. You should choose a caretaker who is conscientious and who can spend the first night with you.

Patients who undergo fat grafting surgery are extremely satisfied with their surgery and their more youth appearing faces, improved body contour, or more robust breast mound shape. By providing a thorough preoperative workup, a safe intraoperative course, and frequent postoperative visits, patients should expect a speedy recovery and effective postoperative results.

Since fat grafting surgery will require general anesthesia or intravenous sedation, it must be performed in an operating room that is part of a hospital institution or outpatient surgery center. Less frequently, patients may be operated on in an in-house office based operating room, but it is of utmost importance for patients to make sure that the office facility is accredited by a surgical accreditation body such as AAAASF.

For large facial fat transfer/grafting or breast augmentation or breast reconstruction revision general anesthesia is required. For correction of small contour deformities intravenous sedation may be utilized.

Patients will awaken from general anesthesia or intravenous sedation to find their fat grafting harvest sites covered by a compression dressing. The compression dressing ensures that areas which were liposuctioned turn our smooth in contour. When transferring fat to the body and/or breast areas, grafted areas will be wrapped with smooth compression dressings to ensure a smooth contour and to ensure that fat cells don’t migrate from their transplanted positions. When fat is transplanted to the face and lips, patients are asked to avoid unnecessary compression especially at nights by sleeping upright with several pillows to cushion each side of the face. Swelling and bruising is typical over grafted sites as over-correction and filling is recommended as up to 30 to 40 % of grafted fat volume is lost over one year period. Patients will notice resolution of swelling over one to two weeks. Arnica gel is recommended for patients demonstrating increased bruising postoperatively. Patients are asked to avoid strenuous physical activity for the first two weeks in order to avoid inadvertent bleeding. Patients can expect full recovery and satisfactory aesthetically pleasing results one month following surgery. Patients ma plan important social engagements as early as 4 weeks following surgery.

Patients can expect to return to work at 1 to 2 weeks following surgery if they work in the back office and do not have to be fully presentable. For patients who deal with consumers or are in sales, 2 to 3 weeks off of work may be more prudent. Finally, if patients have physically strenuous jobs, then two weeks of down time is recommended prior to return to work.

There are several side effects that have been associated with fat grafting surgery and included:

a) Prolonged swelling up to 2 to 3 weeks is not uncommon due to over filling of fat that is performed to compensate for an expected 30 to 40 % of fat graft loss that is observed over the first year following fat transfer. Most patients will notice aesthetically pleasing results at 2 weeks following surgery and stable volumes of correction and filling at one month following surgery.

b) Temporary bruising is often associated with fat grafting surgery due to the extent of tissue trauma that is created by fat harvesting and injection techniques. Bruising is minimized by compression dressings and ensuring that patients due not have any blood clotting disorders. Most bruising subsides within 1 to 2 weeks.

c) Temporary numbness is not uncommon and secondary to inadvertent injury to small sensory nerves which are traumatize by the mechanical action of fat harvesting and injection cannulas. Fortunately, patients should expect a full return of sensation as these nerves even when traumatized will regenerate and re-establish sensation.

d) Under correction void spaces, wrinkles, folds, contour deformities, or breast mound shapes is not uncommon as patients should expect 30 to 40% of volume loss that becomes apparent over the first year following surgery. Despite this expected volume loss, most patients are ecstatic with their postoperative observed volume corrections.

a) Deep vein thrombosis (DVT) may occur in the legs immediately following surgery requiring general anesthesia. DVT refers to the clotting off of leg veins which may result in compromised blood flow return from the legs; a more critical consequence may develop from this clot if it is dislodged and travels to the lungs causing a pulmonary emboli. Although rare, pulmonary emboli are the leading cause of death following surgery. Measures are taken intraoperatively to avoid such a complication.

b) Local skin or fat infection is uncommon and associated with individual patients with poor healing tendencies secondary to medical illnesses. Diabetes, nutritional deficiencies, and smoking are to blame for local infections. Well controlled sugar levels in diabetic patients, optimizing nutrition, and cessation of smoking are critical to avoiding infections.

c) Skin tissue compromise leading to skin loss is rare following fat grafting surgery and is associated with filling of scarred tissues due to increased degree of undermining and tunneling required to transfer fat cells. Smokers are urged to stop smoking for 4 weeks prior to and for 6 weeks following surgery in order to minimize skin tissue compromise.

d) Fat emboli syndrome is a rare risk factor that can be life threatening if not detected in the early postoperatively. This condition is caused by transferred fat cells entering major blood vessels and being dispursed and getting clogged in life sustaining organs. Patients may present with a multitude of symptoms ranging from uncontrolled hypertension, to chest pain, lightheadedness, confusion, and difficulty breathing. Patients require immediate admission to a hospital for supportive therapy with intravenous fluids and possible respiratory support until these fat cells self dissolve.